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大鼠背部20%光辐射Ⅲ度烧伤7天后的焦痂提取液及1:4、1:8稀释液能对正常大鼠肝线粒体呼吸产生明显的抑制作用,相同方法制成的正常皮提取液只呈轻度抑制,1:4稀释液已无抑制作用,两者丙二醛含量相差悬殊,丙二醛含量与抑制率呈相关,但进一步分析表明这种相关为共存现象,丙二醛含量增高不是呼吸率下降的直接原因。丙二醛增高与膜脂双层的破坏有关,内膜能化作用实验表明,当膜脂受到一定程度破坏时,能化作用受到抑制。然而在能化作用未表现异常时,呼吸率已呈一定程度抑制,故呼吸率抑制还受到提取液其他组分的影响。
The eschar extract and the 1: 4 and 1: 8 dilutions after 7 days of 20% light irradiation in the back of rats on the third degree burn could obviously inhibit the respiration of the normal rat liver mitochondria, and the normal skin extract made by the same method Only a mild inhibition, 1: 4 dilution has no inhibitory effect, the two malondialdehyde content of the difference, the malondialdehyde content and inhibition rate was correlated, but further analysis showed that this correlation is the coexistence phenomenon, malondialdehyde content Increase is not the direct cause of decreased respiratory rate. Increased malondialdehyde and membrane lipid bilayer damage, endometrial energy experiments show that when the membrane lipid is damaged to some extent, the role of energy is inhibited. However, in the absence of abnormal energy function, the respiratory rate has been inhibited to a certain extent, so the inhibition of respiratory rate is also affected by the other components of the extract.