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胰岛素抵抗是正常妊娠的特征,更是妊娠糖尿病发生的病理生理基础。妊娠肥胖是妊娠糖尿病发生的重要风险因素,自由脂肪酸则是联系肥胖和胰岛素抵抗的中介,它在正常妊娠和妊娠糖尿病女性血中的水平明显升高。升高的自由脂肪酸水平可通过多种途径引起胰岛素抵抗,在妊娠糖尿病的发生中起着一定的作用。自由脂肪酸有望成为治疗妊娠糖尿病的新靶点。现对自由脂肪酸与胰岛素抵抗和妊娠糖尿病的关系作一综述。
Insulin resistance is a characteristic of normal pregnancy, but also the pathophysiology of gestational diabetes mellitus. Pregnancy obesity is an important risk factor for gestational diabetes mellitus, while free fatty acid is an intermediate linked with obesity and insulin resistance. It is significantly elevated in normal pregnant and gestational diabetic women. Elevated free fatty acid levels can lead to insulin resistance through a variety of pathways, play a role in the development of gestational diabetes. Free fatty acids are expected to become a new target for the treatment of gestational diabetes. Now the relationship between free fatty acids and insulin resistance and gestational diabetes mellitus is reviewed.