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方法：采用高效液相色谱荧光检测法分别测定了冠心病及脑血管病患者和健康人的血浆总高半胱氨酸（Ｈｃｙｓ）含量，以探讨血浆Ｈｃｙｓ与心，脑血管硬化病变之间的关系。结果：冠心病与脑卒中患者血浆Ｈｃｙｓ显著高于健康人。冠心病患者中，恶化型劳累性心绞痛患者血浆Ｈｃｙｓ显著高于陈旧性心肌梗塞患者。结论：血浆Ｈｃｙｓ水平随着冠心病程度加重而增加，但脑梗塞与脑溢血患者血浆总Ｈｃｙｓ水平无显著性差异
Methods: Plasma total homocysteine (Hcys) levels in patients with coronary heart disease and cerebrovascular disease and healthy people were measured by high performance liquid chromatography (HPLC) fluorescence detection to investigate the relationship between plasma Hcys and cardiovascular and cerebrovascular diseases relationship. Results: Plasma Hcys levels in patients with coronary heart disease and stroke were significantly higher than those in healthy subjects. Among patients with coronary heart disease, plasma Hcys was significantly higher in patients with decompensated exertional angina than in patients with old myocardial infarction. Conclusion: Plasma Hcys level increased with the severity of coronary heart disease, but there was no significant difference in total Hcys level between patients with cerebral infarction and cerebral hemorrhage