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为了进一步探讨急性高山病(AMS)的生理学评价指标,先对15名男性健康青年在海拔2261及3417m处进行心肺功能运动试验.结果观察到低氧通气及心搏反应以及动脉血氧饱和度(Sao_2)变化出现较早且敏感。随后对90名男性进入海拔4520m及攀登5620m过程中发生AMS时进行症状学调查,并证实静息动脉血氧分压(Pao_2)和肺泡一动脉氧阶差(AaDO_2)大小与AMS严重程度关系密切。在运动负荷(Vo_(2submax))时,测定静息及运动时最大心率差值(HRD)、动脉二氧化碳分压差值(Paco_2D)及动脉血氧饱和度差值(Sao_2D),由此求得HRD/Sao_2D及Paco_2D/Sao_2D两项指标,分别反映低氧心搏及通气反应能力。对AMS的判别具有敏感性,与以症状学判别相比,总吻合率达92.2％。
To further explore the physiological evaluation of acute mountain sickness (AMS), fifteen male healthy youths were tested for cardiopulmonary exercise at 2261 and 3417m above sea level.Results Hypoxic ventilatory and cardiac responses and arterial oxygen saturation ( Sao_2) changes appear earlier and sensitive. Subsequently, 90 men were investigated for their symptoms when AMS occurred at an elevation of 4520 m and a climb of 5620 m, and confirmed that the resting arterial oxygen pressure (Pao_2) and the size of the alveolar-aorta oxygen level difference (AaDO_2) were closely related to the severity of AMS . The maximum heart rate difference (HRD) at rest and exercise, Paco_2D difference and Sao_2D between arterial oxygen saturation were measured at exercise load (Vo 2submax) HRD / Sao_2D and Paco_2D / Sao_2D two indicators, respectively, reflect the ability of hypoxic heartbeat and ventilation response. AMS discriminant sensitivity, compared with the symptom discrimination, the total anastomosis rate of 92.2%.