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目的观察E838对环磷酰胺所致小鼠损伤的保护作用。方法对小鼠采用连续5天腹腔注射E838药物,从第3天同时给予环磷酰胺(CTX),阳性对照为茜草双酯,观察外周血白细胞、骨髓有核细胞数、内源性脾结节形成(CFU-S)、脾脏指数及胸腺指数的变化。结果E838可明显减轻化疗所致小鼠免疫功能的抑制,并可使化疗后小鼠的体重恢复增长,白细胞、骨髓有核细胞和CFU-S明显高于对照组,差异有统计学意义(P<0.05)。中、高剂量组白细胞与茜草双酯组比较,差异有统计学意义(P<0.05)。结论提示E838具有对抗化疗损伤的作用。
Objective To observe the protective effect of E838 on cyclophosphamide induced injury in mice. Methods The mice were injected intraperitoneally with E838 for 5 days. Cyclophosphamide (CTX) was also given on the third day. The positive control was Rubiacetate. The numbers of peripheral blood leukocytes, bone marrow nucleated cells, endogenous splenic nodules Formation (CFU-S), spleen index and thymus index changes. Results E838 could significantly reduce the inhibition of chemotherapy-induced immune function in mice and restore the weight of mice after chemotherapy. The levels of white blood cells, bone marrow nucleated cells and CFU-S were significantly higher than those of the control group (P <0.05). There was significant difference between the middle and high dose leucocytes and the malathion (P <0.05). The conclusion suggests that E838 has the effect against chemotherapy damage.