目的 :观察诺和灵 30R(Norolin 30R)联用倍欣对磺脲类药物继发失效 (SFS)的 2型糖尿病的疗效。方法 :将 30例SFS的患者停用磺脲类药 ,改用诺和灵 30R和倍欣 (Basen ,Voglibose)联合治疗 ,前后自身对照。结果 :空腹血糖 (FBG)和餐后 2小时血糖 (2hBG)分别从治疗前 (15 5± 3 6 )mmol/L和 (2 6 9± 5 3)mmol/L降至 (6 8± 0 7)mmol/L和 (9 5± 1 2 )mmol/L(P均 <0 0 0 1) ,平均住院时间为 17 4± 5 8天。结论 :诺和灵 30R和倍欣联用可在短期内有效控制SFS患者的血糖水平 ,是治疗SFS的有效方法 Objective: To observe the effect of Norinor 30R combined with bexin on type 2 diabetes mellitus with secondary failure of sulfonylureas (SFS). Methods: Thirty sulfamethoxazole was discontinued in 30 SFS patients, and then treated with combination of norepinephrine 30R and Basen (Voglibose) before and after self-control. Results: The fasting blood glucose (FBG) and 2 hours postprandial blood glucose (2hBG) decreased from (15 5 ± 36) mmol / L and (269 ± 53) mmol / L to ) mmol / L and (95 ± 1 2) mmol / L (all P <0 0 01). The average hospital stay was 17 4 ± 58 days. CONCLUSION: Novolin 30R combined with timesxin can effectively control the blood sugar level of patients with SFS in a short period, which is an effective way to treat SFS