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目的:观察红花黄色素对大鼠实验性心肌缺血的影响。方法:大鼠舌下静脉注射垂体后叶素(Pit)1u/kg制备急性心肌缺血模型,观察红花黄色素对大鼠心肌缺血百分率的影响;大鼠皮下注射盐酸肾上腺素0.8mg/kg加冰水刺激复制大鼠急性血瘀证模型,观察红花黄色素对急性血瘀证大鼠血液流变性的影响;小鼠常压耐缺氧实验,观察红花黄色素对小鼠耐缺氧能力的影响。结果:红花黄色素18、9、4.5 mg/kg舌下静脉给药能显著对抗Pit致大鼠心肌缺血百分率;降低“血瘀症”模型大鼠的全血比黏度、血浆比黏度、红细胞压积及纤维蛋白原含量;明显延长小鼠常压耐缺氧时间。结论:红花黄色素对大鼠急性心肌缺血具有保护作用,其作用与降低缺血百分率,改善血液流变学和减少心肌耗氧等有关。
Objective: To observe the effects of safflower yellow pigment on experimental myocardial ischemia in rats. METHODS: A rat model of acute myocardial ischemia was established by intravenous injection of pit 1u / kg into the sublingual vein to observe the effect of safflower yellow on the percentage of myocardial ischemia in rats. Rats were injected subcutaneously with epinephrine hydrochloride 0.8mg / kg of ice water to stimulate the replication of acute blood stasis model rats to observe the effect of safflower yellow pigment on the blood rheology of rats with acute blood stasis syndrome; hypoxia tolerance test in mice to observe the effect of safflower yellow pigment on mice Effects of hypoxia. Results: Sublingual intravenous administration of safflower yellow pigment at doses of 18, 9, and 4.5 mg / kg significantly inhibited the percentage of myocardial ischemia induced by Pit and decreased the whole blood viscosity, plasma ratio Viscosity, hematocrit and fibrinogen content; significantly prolong the hypoxia tolerance time of mice. CONCLUSION: Safflower yellow has a protective effect on acute myocardial ischemia in rats, and its effect is related to decreasing the percentage of ischemia, improving hemorrheology and reducing myocardial oxygen consumption.