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目的探讨影响贲门癌切除术后长期生活的因素。方法对584例贲门癌切除术后生存10年以上的病例进行回顾性分析。结果本组10年生存率为17.1%。肿瘤的病理分期、分化程度、大体类型、瘤体大小对10年生存率的影响均有统计学意义(P<0.05)。有无淋巴结转移对10年生存率的影响有统计学意义(P<0.01)。伴有切端癌残留、癌栓形成、肿瘤浸润浆膜、手术切除性质,以及性别、年龄、病程等对10年生存率影响无统计学意义(P>0.05)。结论贲门癌的早期发现、早期诊断、早期切除治疗仍是提高其10年生存率的关键。切端癌残留、癌栓形成、手术切除性质等因素对10年生存率的影响尚待进一步探讨。
Objective To investigate the factors affecting long-term life after resection of cardia cancer. Methods A retrospective analysis was performed on 584 patients who survived more than 10 years after cardiac resection. Results The 10-year survival rate of this group was 17.1%. The pathological staging, differentiation degree, gross type and tumor size had statistical significance (P <0.05) in 10-year survival rate. The effect of lymph node metastasis on the 10-year survival rate was statistically significant (P <0.01). There was no significant difference in the 10-year survival rate with the incidence of residual cancer, thrombus formation, tumor-infiltrating serosal invasion, surgical resection, gender, age and course of disease (P> 0.05). Conclusion The early detection of cardia cancer, early diagnosis and early excision are the keys to improve the 10-year survival rate. Incision of end-cancer, thrombosis, the nature of resection and other factors on the 10-year survival rate remains to be further explored.