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背景:短暂性脑缺血发作(transientischemiaattack,TIA)是临床常见的脑血管病之一,采用客观评测方法对其高级神经活动认知功能损害进行评估。目的:研究TIA患者的事件相关电位(P300)的变化,探讨TIA患者的认知损害及可能的机制。设计:以诊断为依据,病例对照研究。地点和对象:在兰州军区乌鲁木齐总医院神经内科门诊及住院诊治的TIA患者31例(TIA组),其中颈内动脉系统9例,椎基底动脉系统22例对照组均为来院体检的健康人30例。干预:对TIA患者及正常对照组进行简易精神状态检查法(MMSE)、听觉oddball刺激序列P300检测及神经系统查体。主要观察指标:MMSE评定分值,P3波潜伏期及P3波幅测定。结果:TIA组的MMSE评分犤(27.13±2.54)分犦,与对照组犤(29.02±1.35)分犦比较,差异有显著性意义(t=2.213,P<0.05)。P3波潜伏期TIA组犤(348.21±20.33)ms犦与对照组犤(330.32±30.12)ms犦比较,差异有显著性意义(t=2.732,P<0.01);椎基底动脉系统TIA比颈内动脉系统TIA的P3波潜伏期延长犤(350.32±31.21)ms,(339.32±27.88)ms犦,差异有显著性意义(t=2.479,P<0.05);TIA患者的P3波潜伏期延长与TIA患者的发作次数呈正相关(r=0.383,P<0.01),与MMSE评分呈负相关(r=-0.259,P<0.05)。结论:TIA患者的P3波潜伏期显著延长,存在早期认知功能的
BACKGROUND: Transient ischemic attack (transient ischemic attack, TIA) is one of the most common cerebrovascular diseases in clinical practice. Objective assessment of cognitive impairment of advanced neural activity was performed by objective evaluation. Objective: To study the changes of event-related potentials (P300) in patients with TIA and to explore the possible mechanism of cognitive impairment in patients with TIA. Design: Based on diagnosis, case-control study. Location and Subjects TIA patients (TIA group) were diagnosed and treated in Department of Neurology, Urumqi General Hospital of Lanzhou Military Region. TIA patients included 9 cases of internal carotid artery system and 22 cases of vertebrobasilar system control group. example. Intervention: Mini-mental state examination (MMSE), auditory oddball stimulus sequence P300 and neurological examination were performed in TIA patients and normal control group. MAIN OUTCOME MEASURES: MMSE score, P3 latency and P3 amplitude. Results: The MMSE score of TIA group was significantly lower than that of control group (27.13 ± 2.54), which was significantly lower than that of control group (29.02 ± 1.35) (t = 2.213, P <0.05). Compared with the control group, the TIA group (348.21 ± 20.33) ms in P3 wave latency had significant difference (t = 2.732, P <0.01) compared with that in control group (330.32 ± 30.12 ms); TIA in vertebrobasilar artery group was significantly higher than that in internal carotid artery The latency of P3 wave of TIA was (350.32 ± 31.21) ms and (339.32 ± 27.88) ms 犦, respectively. There was significant difference between the two groups (t = 2.479, P <0.05) (R = 0.383, P <0.01), and negatively correlated with MMSE score (r = -0.259, P <0.05). Conclusion: The latency of P3 wave in TIA patients is significantly prolonged, with early cognitive function