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目的:探讨葡萄糖酸锌颗粒辅助治疗儿童疱疹性咽峡炎的效果。方法:选取我院2014年4月至2015年5月收治的疱疹性咽峡炎患儿98例,采用随机数表分为对照组和观察组各49例。对照组行常规治疗:利巴韦林颗粒每天10~15 mg/kg,分3~4次服用;利巴韦林气雾剂喷雾吸入治疗,每4~5 h 1次,2揿/次;酌情给予物理降温、退热药物治疗、静脉营养支持等。观察组在常规治疗基础上加用葡萄糖酸锌颗粒10 mg/d,分2次服用。两组均持续用药5 d,观察患儿临床症状恢复时间、治疗效果及不良反应。结果:观察组治疗过程中未见明显不良反应,总有效率89.80%,高于对照组的73.47%(P<0.05);观察组退热时间、流涎消退时间、咽峡部疱疹消失时间、咽痛消失时间、恢复进食时间分别为(1.28±0.46)d、(2.11±0.69)d、(3.25±0.48)d、(2.41±0.63)d、(1.64±0.55)d,均短于对照组(P均<0.05);观察组治疗后CK-MB、CK水平分别为(13.63±3.85)U/L、(65.28±9.52)U/L,均低于对照组(P均<0.05)。结论:葡萄糖酸锌颗粒辅助治疗儿童疱疹性咽峡炎,可加快临床症状恢复,提高临床疗效。
Objective: To investigate the effect of zinc gluconate granules in the treatment of herpes angina in children. Methods: A total of 98 children with herpetic acidosis from April 2014 to May 2015 in our hospital were selected and randomly divided into control group and observation group of 49 cases. Control group routine treatment: ribavirin particles daily 10 ~ 15 mg / kg, 3 to 4 times taking; ribavirin aerosol spray inhalation every 4 ~ 5 h 1 times, 2 揿 / times; As appropriate, give physical cooling, antipyretic drug therapy, intravenous nutrition support. The observation group on the basis of conventional treatment with zinc gluconate particles 10 mg / d, taken 2 times. Both groups continued to use drugs for 5 days to observe the clinical symptoms of children recovery time, treatment and adverse reactions. Results: The treatment group showed no obvious adverse reactions, the total effective rate was 89.80%, which was higher than that of the control group (73.47%, P <0.05). The observation group’s antipyretic time, the time of salivation, the disappearance of pharyngeal isthmus, (1.28 ± 0.46) d, (2.11 ± 0.69) d, (3.25 ± 0.48) d, (2.41 ± 0.63) d, (1.64 ± 0.55) d respectively, which were shorter than the control group (P <0.05). The levels of CK-MB and CK in the observation group after treatment were (13.63 ± 3.85) U / L and (65.28 ± 9.52) U / L, respectively. Conclusion: The zinc gluconate granule adjuvant treatment of herpes zoster in children can accelerate the recovery of clinical symptoms and improve the clinical curative effect.