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目的：比较国产与进口硝酸异山梨酯注射液治疗冠心病心绞痛的疗效。方法：冠心病心绞痛病人１５２例，其中１０２例（男性６７例，女性３５例，年龄６３±ｓ９ａ）以国产硝酸异山梨酯注射液２０ｍｇ加于５％葡萄糖液５００ｍＬ中静脉滴注，ｑｄ，连用１４ｄ。另外５０例（男性３５例，女性１５例；年龄６４±８ａ）以德国进口硝酸异山梨酯注射液２０ｍｇ加入５％葡萄糖液５００ｍＬ中静脉滴注，ｑｄ，连用１４ｄ。结果：国产组临床总有效率为９４．１％，心电图总有效率为４８．０％，进口组则依次为９６％与５２％；组间比较，Ｐ值均＞０．０５。该药尚有扩张血管、降低血压、减低心肌氧耗，改善左室功能等作用。结论：本药的疗效和作用与进口硝酸异山梨酯注射液相近。
Objective: To compare the efficacy of domestic and imported isosorbide dinitrate injection in the treatment of angina pectoris. Methods: 152 cases of coronary heart disease angina pectoris patients, including 102 cases (67 males, 35 females, age 63 ± s9a) with domestic 20mg isosorbide mononitrate injection plus 5% glucose solution 500mL intravenous infusion, qd, 14d. Another 50 patients (35 males and 15 females; age 64 ± 8a) were infused with 20 mg of isosorbide dinitrate nitrate injection into 500 mL of 5% dextrose solution for qd for 14 days. Results: The total effective rate of domestic group was 94.1%, the total effective rate of electrocardiogram was 48.0% and that of import group was 96% and 52% respectively. The P values were all> 0.05 between groups. The drug is also the expansion of blood vessels, lower blood pressure, reduce myocardial oxygen consumption, improve left ventricular function and so on. Conclusion: The efficacy and effect of this medicine is similar to the imported isosorbide dinitrate injection.