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目的：评估加兰他敏胶囊治疗老年性痴呆和单纯性记忆障碍的疗效。方法：４２ 例老年性痴呆和３２ 例单纯性记忆障碍病人入组，其中３７ 例（ 男性２２例，女性１５ 例，年龄６３ ａ ±ｓ ８ ａ） 用加兰他敏胶囊１０ ｍ ｇ ，ｐｏ ，ｑｉｄ ，另３７ 例（ 男性２２ 例，女性１５ 例，年龄６５ ａ ±７ ａ） 用吡拉西坦胶囊８００ ｍ ｇ ，ｐｏ ，ｔｉｄ ，疗程均为８ ｗ ｋ 。结果：加兰他敏组总有效率７０ ％ ，吡拉西坦组为４０ ％ （ Ｐ＜ ０ ．０１） ，加兰他敏组痴呆病人日 常生活功能也较治疗前有明显提高（ Ｐ＜ ０ ．０１） ，该药不良反应轻。结论：加兰他敏胶囊治疗老年性痴呆安全有效。
PURPOSE: To evaluate the efficacy of galantamine in the treatment of senile dementia and simple memory impairment. Methods: Forty-two patients with senile dementia and 32 patients with simple memory impairment were enrolled in the study. Among them, 37 (22 males and 15 females, age 63 ± 8 years) received galantamine 10 m g, po, qid, and the other 37 cases (22 males, 15 females, 65 a ± 7 years) were treated with piracetam 800 mg, po, tid for 8 weeks. Results: The total effective rate was 70% in galanthamine group and 40% in piracetam group (P <0.01), and the daily life function in patients with galantamine group was significantly higher than that before treatment (P <0 .01), the adverse reactions of the drug light. Conclusion: Galantamine capsules are safe and effective in the treatment of senile dementia.