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目的 :探讨神经肽 Y( NPY)在急性脑梗塞后的动脉变化及病理生理过程中的作用。方法 :采用放射免疫法测定了 3 0例急性脑梗塞患者血浆、尿及脑脊液 ( CSF) NPY的含量和动态变化。结果 :急性脑梗塞患者血浆NPY在发病后 3 d降低 ,7d显著升高 ( P<0 .0 0 1) ,CSF中 NPY在梗塞后 3 d升高 ( P<0 .0 5 )。 2 1d时血浆及CSF中的 NPY均降至正常 ,两者的变化无相关性 ( P>0 .0 5 )。CSF中 NPY在皮层下梗塞时升高 ( P<0 .0 5 ) ,而血浆 NPY与梗塞部位无明显关系。尿中 NPY含量在急性脑梗塞后变化不明显 ( P>0 .0 5 )。结论 :NPY参与了急性脑梗塞的发生和发展过程
Objective: To investigate the effect of neuropeptide Y (NPY) on arterial changes and pathophysiology after acute cerebral infarction. Methods: Radioimmunoassay was used to determine the content and dynamic changes of NPY in plasma, urine and cerebrospinal fluid (CSF) of 30 acute cerebral infarction patients. Results: NPY of plasma in patients with acute cerebral infarction decreased 3 days after onset and increased significantly at 7 days (P <0.01). NPY in CSF increased 3 days after infarction (P <0.05). NPY in both plasma and CSF decreased to normal on day 21 and no correlation was found between the two (P> 0.05). NPY in CSF was increased in subcortical infarction (P <0.05), while plasma NPY had no significant relationship with infarct site. The urinary NPY content did not change significantly after acute cerebral infarction (P> 0.05). Conclusion: NPY is involved in the occurrence and development of acute cerebral infarction