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同种骨髓移植的主要障碍是由遗传所决定的供、受者的组织相容性。当供、受者为同种异基因型(Allogeneic)移植,其不同程度的组织不相容性就会形成双相性免疫障碍,产生移植物抗宿主病(GVHD)和宿主抗移植反应(HVGR)。Bontin 总结了1964年以前骨髓
The main obstacle to allogeneic bone marrow transplantation is the genetic compatibility of donor and recipient. When donor and recipient are allogeneic, their varying degrees of tissue incompatibility develop bipolar disorder, resulting in graft versus host disease (GVHD) and host graft rejection (HVGR) . Bontin summarizes bone marrow before 1964