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研究了用不同剂量（７５、５０、２５、１０ｍｇ／ｋｇ）ＲＵ４８６阻断公雏鸡糖皮质激素受体１天或连续３天免疫指标变化情况。ＲＵ４８６７５和５０ｍｇ／ｋｇ阻断ＧＲ２４ｈ，公雏鸡脾淋巴细胞ＩＬ－２、ＩＦＮ诱生活性和Ｔ、Ｂ淋巴细胞增殖活性降低（Ｐ＜００１），外周血淋巴细胞、单核细胞、ＡＮＡＥ＋细胞减少（Ｐ＜００１）；胸腺、脾脏、法氏囊的体重比减小（Ｐ＜００１）。每日ＲＵ４８６５０ｍｇ／ｋｇ连续３天阻断ＧＲ功能，上述指标与同剂量ＲＵ４８６阻断ＧＲ２４ｈ鸡比较有进一步下降趋势。２５和１０ｍｇ／ｋｇＲＵ４８６阻断ＧＲ２４ｈ，上述免疫指标无明显变化（Ｐ＞００５）。结果表明，ＲＵ４８６剂量与鸡脾淋巴细胞ＩＬ－２、ＩＦＮ诱生活性和Ｔ、Ｂ淋巴细胞活性变化呈负相关，提示雏鸡免疫功能与免疫细胞的功能性ＧＲ含量成正相关。
The effects of RU486 (75, 50, 25, and 10 mg / kg) on the immunosuppression of 1 day or 3 consecutive days of the glucocorticoid receptor in male chickens were studied. RU48675 and 50mg / kg block GR24h, the activity of IL-2 and IFN induced by spleen lymphocytes and the decrease of T and B lymphocyte proliferative activity (P <001), peripheral blood lymphocytes, monocytes, ANAE + cells (P <001). The body weight ratio of thymus, spleen and bursa decreased (P <001). RU48650mg / kg daily for 3 consecutive days blocked the GR function, the above indicators and the same dose of RU486 block GR24h chicken compared with a further downward trend. 25 and 10mg / kgRU486 block GR24h, no significant change in the immune parameters (P> 0 05). The results showed that RU486 dose was negatively correlated with IL-2, IFN-induced activity and T, B lymphocyte activity in chicken splenic lymphocytes, indicating that the immune function of chicken is positively correlated with the functional GR content of immune cells.