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应用从慢性肝炎病人尿中提取精制的人尿衍生物(human urin derivative,简称 HUD)治疗慢性肝炎,探讨新疗法时效果及肝炎血清学诊断方法。结果①9例难治性肝炎病人投与 HUD,8例(88.9%)谷丙转氨酶(GPT),谷(?)转氨酶(GOT)转为正常。其中5例服药中止后仍维持正常(?),(?)3例服药中止后再度上升,1例不改变。②从确诊为血清性肝炎及流行性肝炎病人的尿中提取 HUD,分别作为抗原注射小鼠,制成免疫血清。用这种血清与从GOT,GPT,乳酸脱氨酶(LDH)升高的病人尿中制成的 HUD 作沉淀反应。可将肝炎分为两种类型,甲型(流行性)肝炎,乙型(血清性)肝炎。用这种方法试验34例,结果为甲型18例(52.9%);乙型15例
Application of purified human urin derivative (HUD) from patients with chronic hepatitis to treat chronic hepatitis, to explore the effect of new therapy and serological diagnosis of hepatitis. Results ① Nine patients with refractory hepatitis were treated with HUD. Eight cases (88.9%) of GPT and GOT turned normal. Among them, 5 patients remained normal after discontinuation of medication (?), (?) 3 patients rose again after discontinuation of medication, and 1 patient did not change. ② HUD was extracted from the urine of patients diagnosed as having serologic hepatitis and epidemic hepatitis, and were respectively injected as antigens to make immune sera. This serum was used as a precipitation reaction with HUD made in the urine of patients with elevated GOT, GPT, lactate deaminase (LDH). Hepatitis can be divided into two types, type A (epidemic) hepatitis, type B (serum) hepatitis. 34 cases were tested in this way, with 18 cases (52.9%) of type A and 15 cases of type B.