心脏毒性标志物在评价药物诱导的心脏毒性方面具有重要意义,近年来,心脏毒性生物标志物研究取得了很大的进步,新的标志物在敏感性、特异性及预测价值方面都超越了传统标志物,但仍存在一定的局限性,需要开展更多的研究和验证工作,尤其是将临床前生物标志物向临床转化的研究工作。本文综述了心脏毒性生物标志物近年来的研究进展及其局限性。 Cardiotoxicity markers have important implications for the evaluation of drug-induced cardiotoxicity. In recent years, great advances have been made in the study of cardiotoxic biomarkers. The new markers surpass the traditional ones in terms of sensitivity, specificity and predictive value However, there are still some limitations. More research and validation work is needed, especially the research on the clinical transformation of preclinical biomarkers. This article reviews the recent advances and limitations of cardiotoxic biomarkers.