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目的 测定甲亢患者的骨密度与骨代谢生化指标 ,探讨甲亢骨质疏松发生的机理。方法 应用双能 X线测定仪 (DEXA) ,检查 6 1例甲亢患者骨密度 (BMD)的变化 ,同时测定血清骨特异性碱性磷酸酶 (B- ALP)、骨钙素 (BGP)、 型前胶原末端肽 (PICP)、抗酒石酸盐酸性磷酸酶 (TRAP)、尿吡啶啉(Pyd)、脱氧吡啶啉 (D- Pyd)的水平。结果 与对照组比较 ,甲亢患者的各项骨代谢生化指标均明显升高(P<0 .0 1) ,且与 FT4 呈正相关。结论 甲亢时反映成骨细胞活性的 B- AL P、BGP、PICP和反映破骨细胞活性的 TRAP、Pyd和 D- Pyd均升高 ,以破骨指标升高更明显 ,呈高转换型骨质疏松。
Objective To determine the bone mineral density and biochemical markers of bone metabolism in patients with hyperthyroidism and to explore the mechanism of osteoporosis. Methods The bone mineral density (BMD) in 61 hyperthyroidism patients was examined by dual energy X-ray analyzer (DEXA). Serum bone specific alkaline phosphatase (B-ALP), osteocalcin (BGP) Procollagen peptide (PICP), tartrate-resistant acid phosphatase (TRAP), urinary Pyd, and deoxypyridinoline (D-Pyd). Results Compared with the control group, the biochemical indexes of bone metabolism in hyperthyroidism patients were significantly increased (P <0.01), and positively correlated with FT4. CONCLUSIONS: B-ALP, BGP and PICP, which reflect the activity of osteoblasts during hyperthyroidism, and TRAP, Pyd and D-Pyd which reflect the activity of osteoclasts were all increased, and the indexes of osteoclasts increased more obviously with high conversion type loose.