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表观遗传学的改变,DNA甲基化和核染色质结构的破坏,目前被认为是肿瘤发生过程中最普遍的的特征。这种现象也毫无例外的发生在儿童脑的髓母细胞瘤中。尽管从目前基因组学的研究中,对髓母细胞瘤取得较大的进展,然而四种不同分子亚型(WNT、SHH、Group 3及Group 3)间均存在许多不同的特点,许多案例仍缺乏明显的基因启动子。作者对34个人类和5个鼠类动物的髓母细胞瘤,加上8个人类和3个鼠类正常对照组进行深入分析,包括对整个基因组
Epigenetic changes, DNA methylation and disruption of nuclear chromatin structure are now considered to be the most common features of tumorigenesis. This phenomenon is also without exception occurred in the brain of children with medulloblastoma. Although there has been considerable progress in medulloblastoma from the current genomic studies, there are many different characteristics among the four different molecular subtypes (WNT, SHH, Group 3 and Group 3), and many cases are still lacking Obvious gene promoter. The authors performed an in-depth analysis of medulloblastoma in 34 human and 5 murine animals, plus 8 human and 3 murine normal control groups, including the entire genome