采用体外细胞培养法，建立了内皮－单个核细胞联合培养模型，观察了该模型中单个核细胞形态和数量的变化。所见３种形态的单个核细胞，分别称为Ⅰ型、Ⅱ型和Ⅲ型细胞。对３型细胞进行了形态的描述和定量的观察，认为培养内皮细胞对单核细胞向巨噬细胞分化有诱导作用。该方法简便、安全、可靠，是研究内皮一单个核细胞粘附的理想模型。 The in vitro cell culture method was used to establish the endothelial-mononuclear cell co-culture model. The morphological and quantitative changes of mononuclear cells in the model were observed. The three forms of mononuclear cells seen are type I, type II and type III cells, respectively. Morphological description and quantitative observation of type 3 cells suggest that endothelial cells are cultured to induce monocyte differentiation into macrophages. The method is simple, safe and reliable, and is an ideal model to study the adhesion of endothelial mononuclear cells.