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目的:研究分化抑制因子-1(Id-1)在人大肠癌组织中的表达及其与临床病理特征的关系。方法:应用免疫组织化学方法(SP法)检测Id-1在56例大肠癌组织及56例远癌肠黏膜中的表达水平,并分析其与临床病理特征的关系。结果:在大肠癌组织中Id-1的过表达率为80.4%,在远癌肠粘膜中过表达率为12.5%,两组比较差异有统计学意义(P<0.01)。Id-1过表达与大肠癌Dukes分期及淋巴结转移有关(P<0.05),而与患者年龄、性别、肿瘤组织分化程度无关(P>0.05)。结论:Id-1过表达可能参与大肠癌演进,Id-1可作为判断大肠癌恶性程度和预后的指标。
Objective: To investigate the expression of Id-1 in human colorectal carcinoma and its relationship with clinicopathological features. Methods: The expression of Id-1 in 56 cases of colorectal carcinoma and 56 cases of distal colon mucosa was detected by immunohistochemical method (SP method), and its relationship with clinicopathological features was analyzed. Results: The overexpression rate of Id-1 in colorectal carcinoma was 80.4%, and the rate of overexpression in distant mucosa was 12.5%. There was significant difference between the two groups (P <0.01). The overexpression of Id-1 was correlated with Dukes staging and lymph node metastasis (P <0.05), but not with the age, sex and tumor differentiation (P> 0.05). Conclusion: Id-1 overexpression may be involved in the progression of colorectal cancer. Id-1 may be used as an indicator of malignancy and prognosis of colorectal cancer.