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为了研究罗汉果浓缩汁及罗汉果甜甙对小鼠血脂代谢的影响,利用高脂饲料饲喂ICR小鼠建立高血脂动物模型。饲养60d后,测定各组小鼠血清总胆固醇(TC)、甘油三酯(TG)及高密度脂蛋白胆固醇(HDL-C)含量。结果表明,罗汉果浓缩汁组及罗汉果甜甙组小鼠血清平均TC含量分别为98.14mg/dL和86.07mg/dL,分别比高脂模型组降低了17.3%和27.5%,效果显著(P<0.05);TG含量分别为153.54mg/dL和118.98mg/dL,分别降低了28.4%和44.5%,显著低于高脂模型组(P<0.05);HDL-C平均含量分别为73.89mg/dL和70.01mg/dL,分别升高了34.4%和27.3%,达到显著水平(P<0.05)。因此罗汉果浓缩汁及罗汉果甜甙均有正向调节机体血脂代谢的生理功能。
In order to study the effect of Luo Han Guo concentrated juice and Luo Han Guo sweet glycosides on blood lipid metabolism in mice, high fat diet was used to feed ICR mice to establish a high blood lipid animal model. After 60 days of feeding, serum total cholesterol (TC), triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels were measured in each group of mice. The results showed that the average serum TC content in mice of Siraitia grosvenori juice group and Luohanguo sweet wolfberry group was 98.14 mg/dL and 86.07 mg/dL, respectively, which was 17.3% and 27.5% lower than that in the high-fat model group, respectively (P<0.05). TG content was 153.54 mg/dL and 118.98 mg/dL, respectively, decreased 28.4% and 44.5%, respectively, significantly lower than the high-fat model group (P<0.05); the average HDL-C content was 73.89 mg/dL, respectively. 70.01mg/dL, respectively, increased 34.4% and 27.3%, reaching significant levels (P <0.05). Therefore, Luo Han Guo concentrated juice and Luo Han Guo sweet wolfberry have positive physiological functions regulating the metabolism of blood lipids.