论文部分内容阅读
色甘酸钠可抑制由抗原抗体反应引起的脱颗粒所造成的组胺等化学递质的游离,因而它具有抗过敏作用。但口服无效。最近,新研制的Oxatomide(KW-4345)具有与色甘酸钠同样的作用机理,且口服有效。该药化学名为1-{3-[4-(二苯基甲基)-1-哌嗪基]丙基}-1,3-二氢-2H-苯并咪唑-2-酮。对大鼠的PCA反应、土拨鼠的过敏性致死、狗的蛔虫过敏等,口服给药均能明显抑制过敏反应。另外,它也有抗组胺作用,对组胺皮肤反应的抑制作用十分明显,但不影响组胺对心房组织的作用,无H_2受体阻断作用。本品口服吸收迅速,大约1小时后达到最高
Sodium cromoglycate suppresses the liberation of chemical mediators such as histamine due to degranulation caused by the antigen-antibody reaction, and thus it has an anti-allergic effect. But orally invalid. Recently, newly developed Oxatomide (KW-4345) has the same mechanism of action as cromolyn and is orally effective. The chemical name of this medicine is 1- {3- [4- (diphenylmethyl) -1-piperazinyl] propyl} -1,3-dihydro-2H-benzimidazol-2-one. PCA response to rats, woodchuck allergic to death, dog roundworm allergy, oral administration can significantly inhibit the allergic reaction. In addition, it also has anti-histamine effect, inhibit the histamine skin reaction is very obvious, but does not affect the histamine on the role of atrial tissue, without H 2 receptor blockade. This product quickly absorbed orally, reaching the highest after about 1 hour