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目的 :调查北京儿童医院2004—2010年神经母细胞瘤患儿的疾病谱特征,为儿童神经母细胞瘤早期诊断提供有效数据。方法 :选择2004—2010年北京儿童医院肿瘤外科收治的经病理确诊为神经母细胞瘤的患儿168例。采用描述统计方法分析神经母细胞瘤患儿的疾病谱特征。结果 :在168例研究对象中,Ⅱ期和Ⅲ期神经母细胞瘤患儿分别占20.73%(34例)和29.27%(48例)。神经母细胞瘤手术患儿为90例,其中67例(74.44%)完全切除,22例(24.44%)部分切除,1例(1.11%)因肿瘤巨大而无法切除。神经母细胞瘤肿瘤分期与患儿年龄相关(P=0.003),肿瘤分期与手术切除预后密切相关(P=0.046)。与Ⅰ期和Ⅱ期患儿相比,Ⅲ期和Ⅳ期患儿的手术切除效果和预后均较差。结论 :患儿年龄与神经母细胞瘤肿瘤分期相关。肿瘤分期影响神经母细胞瘤的手术治疗结局。
Objective: To investigate the characteristics of the disease spectrum of children with neuroblastoma in Children’s Hospital of Beijing from 2004 to 2010, and to provide effective data for the early diagnosis of neuroblastoma in children. Methods: A total of 168 children with pathologically diagnosed neuroblastoma were enrolled in the Department of Oncology, Beijing Children’s Hospital, 2004-2010. Descriptive statistics were used to analyze the disease profile of children with neuroblastoma. Results: Of the 168 subjects, 20.73% (34 cases) and 29.27% (48 cases) of stage II and III neuroblastoma respectively. Among the 90 children with neuroblastoma surgery, 67 (74.44%) were completely resected, 22 (24.44%) were partially resected, and 1 (1.11%) were unresectable due to the size of the tumor. The staging of neuroblastoma was related to the age of the children (P = 0.003). The staging of the tumor was closely related to the prognosis of the resection (P = 0.046). Compared with stage I and stage II children, stage III and IV in children with surgical resection results and prognosis are poor. Conclusion: The age of children is related to the staging of neuroblastoma. Tumor staging affects the outcome of surgical treatment of neuroblastoma.