震颤麻痹又称帕金森氏病(PD)是神经科较常见的疾病。一个世纪以来一直应用抗胆碱能药物(如(?)茄、阿托品、东莨菪硷、安坦、开马君、苯甲托品等)治疗,但都只是经验疗法,疗效也不够理想,且病因始终未阐明。至本世纪六十年代才明确本病主要因纹状体中一对神经递质的功能失去平衡,即多巴胺(DA)减少和乙酰胆碱(ACh)功能过盛所引起,因此 Parkinsonism, also known as Parkinson’s disease (PD), is a neurological common disease. For centuries, anticholinergic drugs such as (?) Atropine, atropine, scopolamine, antan, kaempferol, and benztropine have been used for treatment, but they are only empirical therapies, Etiology has not been elucidated. It was not until the 1960s that the disease was mainly caused by a loss of balance between the function of a pair of neurotransmitters in the striatum, namely, a decrease in dopamine (DA) and hypercapnia of acetylcholine (ACh)