论文部分内容阅读
Schroff 等报道醋炔诺酮肟(17α-乙炔基-17β-乙酰基-19-去甲基-4-雄甾烯-3-酮肟)对大鼠有较好的抗生育作用。我们对醋炔诺酮肟进行了动物抗着床作用和毒性研究,结果如下。实验用小鼠、大鼠、家兔和犬。小鼠在妊娠第2天开始口服醋炔诺酮肟2mg/kg,每天一次,连续3天,有显著的抗着床作用(给药组怀孕率为0%,对照组为90%);和炔诺酮比较,醋炔诺酮肟抗着床效果比炔诺酮大12.5倍。大鼠在妊娠第2天开始,口服醋炔诺酮肟0.5mg/kg,每天一次,连续3天,或在妊娠第2、3天,一次
Schroff et al. Reported that ketoconazole (17α-ethynyl-17β-acetyl-19-nor-methyl-4-androsten-3-one oxime) had a good anti-fertility effect in rats. We tested the anti-nociceptive effects and toxicity of norethindrone acetate. The results are as follows. Experimental mice, rats, rabbits and dogs. Mice were given 2 mg / kg of norgestimate oxime orally on day 2 of gestation once daily for 3 consecutive days with significant anti-implantation (0% pregnancy rate in the dosing group and 90% in the control group); and Compared with norethindrone, norethisterone oxime has anti-implantation effect 12.5 times larger than norethisterone. Rats in the second day of pregnancy, oral administration of norethindrone acetate 0.5mg / kg once a day for 3 days, or in the first two days of pregnancy, once