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目的 :研究高甲状腺激素水平下心肌病理改变与心肌血管紧张素Ⅱ的关系。方法 :给大鼠口服甲状腺片 ,平均每只4mg·d-1,连续 6 0d ,观察心肌病理变化 ,检测左心室肌血管紧张素Ⅱ浓度和总含量。结果 :实验组大鼠心肌有明显病理损伤 ;左心室肌血管紧张素Ⅱ浓度和总含量分别为 (170 .6± 33.2 ) pg·(10 0mg) -1、(2 0 85 .3± 175 .1) pg ,显著高于对照组 (130 .2±2 0 .1)pg·(10 0mg) -1、(10 6 7.4± 15 4 .5 )pg(P <0 .0 5 )。结论 :心肌血管紧张素Ⅱ含量升高是高甲状腺激素水平下心肌损伤的原因之一。
Objective: To investigate the relationship between myocardial pathological changes and myocardial angiotensin Ⅱ in patients with high thyroid hormone. Methods: Thyroid slices were administered orally to rats for an average of 4 mg · d-1 for 60 days. The pathological changes of myocardium were observed. The concentrations and total contents of angiotensin Ⅱ in left ventricular muscle were measured. Results: Myocardium in the experimental group had obvious pathological damage. The concentration and total concentration of angiotensin Ⅱ in the left ventricular muscle were (170.6 ± 33.2) pg · (100mg) -1, (2 0 85.3 ± 175). 1) pg was significantly higher than that of the control group (130 .2 ± 20.1) pg · (10 0 mg) -1, (10 6 7.4 ± 15 4 .5) pg (P <0.05). Conclusion: The increase of myocardial angiotensin Ⅱ is one of the causes of myocardial injury under high thyroid hormone level.