论文部分内容阅读
目的 :探讨长期联合化疗对缓解期成人白血病患者是否有潜在的诱变性。方法 :应用姐妹染色单体交换 (SCE)技术检测 44例白血病患者外周血细胞 SCE率的改变。结果 :初治、复发的急性白血病 (AL)和 CML组患者 SCE频率明显高于 CR- AL 组和正常对照组 ;CR- AL 仍有少部分高 SCE病例 (5 / 16 ) ,而此类病例主要分布在接受联合化疗在 9个疗程以上的 CR- AL 的患者中 (3/ 6 )。结论 :初治、复发 AL 和 CML 患者存在着 DNA的损伤或 DNA修复机制缺陷 ,长期反复联合化疗可能引起部分病例 DNA的不稳定。
Objective: To investigate whether long-term combined chemotherapy may have potential mutagenicity in remission adult leukemia patients. Methods: SCE was used to detect the change of SCE in peripheral blood cells of 44 leukemia patients. Results: The frequency of SCE was significantly higher in patients with newly diagnosed and relapsed acute leukemia (AL) and CML than in CR-AL and normal controls; CR-AL still had a few high-SCE cases (5/16). It was mainly distributed in patients who received combination chemotherapy with more than 9 courses of CR-AL (3/6). Conclusions: In patients with newly diagnosed and relapsed AL and CML, DNA damage or defects in DNA repair mechanisms exist. Long-term repeated combination chemotherapy may cause DNA instability in some cases.