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目的:评价早期干预和早期干预联合高压氧(HBO)治疗新生儿缺氧缺血性脑病(HIE)对患儿预后的影响。方法:将88例中度HIE患儿随机分为干预组A、干预组B和对照组。干预组A、B进行触、听、视觉刺激和前庭功能训练至3个月。干预组A除上述治疗,加用高压氧治疗。每疗程7次,每月1疗程,共3疗程。结果:3月龄、6月龄时智力发育指数(MDI)和心理运动发育指数(PDI)3组比较干预组A最高,干预组B次之,对照组最低。1岁时干预组A、B的发育商无明显差异,但均高于对照组。干预组A、B的后遗症发生率低于对照组。结论:在早期干预基础上配合高压氧治疗对提高患儿3月、6月时发育指数有一定协同作用,但对HIE患儿的远期智能发育的影响尚有待于进一步随访评估。
Objective: To evaluate the effect of early intervention and early intervention combined with hyperbaric oxygen (HBO) on the prognosis of neonates with hypoxic-ischemic encephalopathy (HIE). Methods: 88 children with moderate HIE were randomly divided into intervention group A, intervention group B and control group. Intervention group A, B for touch, hearing, visual stimulation and vestibular function training to 3 months. Intervention group A in addition to the above treatment, plus hyperbaric oxygen therapy. Each treatment 7 times a month, a course of treatment, a total of 3 courses. Results: At the age of 3 and 6 months, the mental development index (MDI) and psychomotor development index (PDI) in the three groups were the highest, the second was in the intervention group B, and the lowest in the control group. At 1 year of age intervention group A, B of the development of no significant difference, but were higher than the control group. The incidence of sequelae in intervention group A and B was lower than that in control group. Conclusion: The combination of hyperbaric oxygen therapy and early intervention has certain synergistic effect on improving the developmental index of children at 3 months and 6 months. However, the impact on long-term intelligence development of children with HIE remains to be evaluated after further follow-up.