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目的:探讨益肾颗粒剂联合霉酚酸酯(MMF)对狼疮性肾炎(LN)患者的神经肽Y(NPY)水平的影响及其临床疗效。方法:将54例狼疮性肾炎患者随机分为治疗组(益肾颗粒剂联合霉酚酸酯组)26例和对照组(单纯用霉酚酸酯组)28例,比较两组治疗后的疗效,并用放射免疫分析法(RIA)检测治疗组和对照组血浆神经肽Y水平。结果:治疗组总有效率明显优于对照组(P<0.05);治疗组患者的临床生化指标也明显优于对照组(P<0.05),治疗组患者的血浆神经肽Y水平也明显的低于对照组(P<0.001)。结论:益肾颗粒剂合霉酚酸酯对LN患者有明确疗效,并对LN患者血浆中神经肽Y水平也有明显的降低作用。
Objective: To investigate the effect of Yishen Granule combined with mycophenolate mofetil (MMF) on neuropeptide Y (NPY) in patients with lupus nephritis (LN) and its clinical efficacy. Methods: 54 patients with lupus nephritis were randomly divided into treatment group (Yishen Granule combined with mycophenolate mofetil) and control group (simple mycophenolate mofetil group), 28 cases were treated. The curative effect was compared between the two groups , And radioimmunoassay (RIA) was used to detect plasma neuropeptide Y levels in the treatment group and the control group. Results: The total effective rate in the treatment group was significantly better than that in the control group (P <0.05). The clinical biochemical indexes in the treatment group were also significantly better than those in the control group (P <0.05). The plasma neuropeptide Y levels in the treatment group were also significantly lower In the control group (P <0.001). Conclusion: Yishen granule combined with mycophenolate mofetil has a definite curative effect on patients with LN and a significant reduction of plasma neuropeptide Y in LN patients.