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目的报告1例多发性毛盘瘤。患者男,31岁。主诉右下肢出现多发性高梁米粒至小豆大小坚实性皮色丘疹15年,左膝关节、左小腿部同样皮损近1年,无自觉症状。方法和结果组织病理显示表皮棘层肥厚,真皮上部为细网状胶原纤维增殖和局灶性黏蛋白沉积,细小血管和神经纤维成分增多,弹力纤维增殖限局于毛囊和表皮突周围。增生毛囊见于病变两侧边缘,呈衣领状向下延伸。超微结构示Merkel细胞-轴突复合体位于表皮下基底板上方,真皮上部见有髓神经纤维。血管超微结构有的基底板显示层状结构,时见血管壁纤维成分增殖,管壁增厚。结论本病罕见,系来源于毛盘的一种错构瘤。
Objective To report a case of multiple hair tumor. Patient male, 31 years old. The main complaint appeared on the right lower extremity multiple sorghum rice to adzuki bean size solid pimples 15 years left knee, left lesion the same skin lesions nearly 1 year, no symptoms. Methods and Results Histopathology showed epidermal acanthosis. The upper dermis was characterized by the proliferation of fine network collagen fibers and the deposition of focal mucin. The composition of small blood vessels and nerve fibers increased. The proliferation of elastic fibers was limited to the periphery of the hair follicles and epidermal processes. Proliferation hair follicles found in the edge of both sides of the lesion, was collar-like downward extension. The ultrastructure shows that the Merkel cell-axon complex is located above the epidermal basal plate and the myelinated nerve fibers are seen in the upper dermis. Some of the vascular ultrastructure of the base plate shows the layered structure, see the proliferation of vascular wall fiber content, wall thickening. Conclusions This disease is rare and is a hamartoma derived from the wool disk.