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目的探讨普萘洛尔对大鼠急性脑梗死致脑心综合征(CCS)时的心电图异常变化及血浆中皮质酮的浓度。方法通过线栓法制备大鼠右侧大脑中动脉缺血模型,连续监测造模后2h标准II导联心电图。将实验大鼠分为正常组、假手术组、CCS组、普萘洛尔组,分别于12h,3d,7d时观察各组大鼠的心电图变化及血浆中皮质酮的浓度。结果普萘洛尔组大鼠心电图异常率降低;在12h时,假手术组、CCS组、普萘洛尔组血浆中皮质酮水平较正常组明显升高。假手术组则快速恢复正常水平;CCS组、普萘洛尔组则在3d,7d时逐渐下降,CCS组在各点时始终高于普萘洛尔组。结论普萘洛尔可能影响脑心综合征大鼠心电图的变化及恢复,在一定程度上可降低应激状态下皮质酮的水平,可能成为防治脑梗死所致脑心综合征的机制之一。
Objective To investigate the abnormal changes of electrocardiogram (ECG) and plasma corticosterone concentration in propranolol on brain-heart syndrome (CCS) induced by acute cerebral infarction in rats. Methods Right middle cerebral artery occlusion (MCAO) model was prepared by the method of thread plug. The standard II lead electrocardiogram was monitored 2h after modeling. The rats were divided into normal group, sham operation group, CCS group and propranolol group. The change of electrocardiogram (ECG) and corticosterone level in plasma were observed at 12h, 3d and 7d respectively. Results The abnormal rate of electrocardiogram was decreased in propranolol group. At 12 h, the plasma corticosterone level in sham group, CCS group and propranolol group was significantly higher than that in normal group. The sham group returned to normal quickly; the CCS group and the propranolol group decreased gradually at 3d and 7d, and the CCS group was always higher than the propranolol group at each point. Conclusion Propranolol may affect the changes and recovery of electrocardiogram in rats with brain-heart syndrome, and may reduce the level of corticosterone under stress, which may be one of the mechanisms of prevention and treatment of cerebral infarction-induced brain-heart syndrome.