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目的探讨慢性阻塞性肺病急性期患者纤溶系统及血小板功能的变化，防治相关的并发症。方法选慢性阻塞性肺病组３４例，无血栓栓塞性疾病对照组２０例，用ＥＬＩＳＡ双抗体夹心放免法及发色底物法分别检测ＧＭＰ－１４０、ｔ－ＰＡ：Ａ活性、 ＰＡＩ： Ａ活性。结果慢性阻塞性肺病患者急性加重期 ＧＭＰ－１４０、 ＡＰＩ： Ａ活性显著高于对照组（ Ｐ＜ ０， ０１）、 ｔ－ＰＡ：Ａ显著低于对照组（ Ｐ ＜ ０． ０１）。结论慢性阻塞性肺病急性期患者具有低纤溶及血小板功能亢进，有血栓形成倾向。
Objective To investigate the changes of fibrinolytic system and platelet function in patients with acute obstructive pulmonary disease (COPD) and to prevent and cure the related complications. Methods 34 patients with chronic obstructive pulmonary disease and 20 patients without thromboembolic disease were enrolled in this study. The activities of GMP-140, t-PA: A, PAI: A activity were detected by ELISA double antibody sandwich radioimmunoassay . Results The levels of GMP-140 and API: A in acute exacerbation of chronic obstructive pulmonary disease were significantly higher than those in control group (P <0.01). The t-PA: A was significantly lower than that in control group (P <0.01). Conclusions Patients with chronic obstructive pulmonary disease have fibrinolytic and platelet hyperfunction with thrombophilia.