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目的探讨25(OH)D与2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)的关系。方法采集T2DM合并NAFLD患者(DNF组,60例),T2DM未合并NAFLD组患者(DM组,60例)及体检健康者(DC组,60例)的血清25(OH)D浓度及生化、C肽和24h尿微量白蛋白(24UAMLB),同时测定血糖参数进行比较。结果 DNF组25(OH)D与Ur(r_s=0.175,P<0.05)呈正相关,与24UAMLB(r_s=-0.145,P<0.05)、AST/ALT(r_s=-0.127,P<0.05)均呈负相关;AST/ALT为25(OH)D的危险因素,尿素为25(OH)D的保护因素。结论合并NAFLD的T2DM患者血清维生素D水平更低;监测血清25(OH)D的水平有助于评估2型糖尿病患者并发非酒精性脂肪性肝病的风险性。
Objective To investigate the relationship between 25 (OH) D and type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease (NAFLD). Methods Serum levels of 25 (OH) D and serum biochemical, C (superscript +) T cells in T2DM patients with NAFLD (DNF group, 60 patients), T2DM patients without NAFLD group (DM group, 60 patients) and healthy subjects (DC group, Peptide and 24h urinary albumin (24UAMLB), blood sugar parameters were measured at the same time for comparison. Results There was a positive correlation between 25 (OH) D and Ur (r_s = 0.175, P <0.05) in DNF group, and was significantly higher than that in 24 UAMLB group (r_s = -0.145, P < Negative correlation; AST / ALT 25 (OH) D risk factors, urea 25 (OH) D protective factor. Conclusion T2DM patients with NAFLD have lower serum vitamin D levels. Monitoring serum 25 (OH) D levels may be helpful in assessing the risk of T2DM in patients with non-alcoholic fatty liver disease.