论文部分内容阅读
目的 观察交替化疗与多药联合化疗治疗晚期儿童神经母细胞瘤的疗效 ,毒性反应及对生存期的影响。方法 对 2 9例晚期神经母细胞瘤的患儿给予术前或术后化疗 ,14例采用COA/VIP或VP方案交替化疗共 15 5疗程 ,15例采用COPE等多药联合化疗共 84疗程。结果 交替化疗组 14例可评价疗效 13例 ,CR 0 ,PR12例 ,NC1例 ,PD 0。有效率 12 / 13(92 .3% )。化疗后手术完整切除率 10 / 13(76 .9% )。多药联合化疗组 15例 ,可评价疗效 11例 ,CR1例 ,PR5例 ,NC3例 ,PD2例 ,有效率 6 / 11(5 4.5 % )。化疗后手术切除率为 5 / 11(4 5 .5 % )。两组比较P <0 .0 5 (X2 检验 ) ,化疗的毒性反应主要表现为骨髓抑制 ,恶心呕吐等 ,均为可逆性。两组生存期比较经秩和检验P >0 .0 5无统计学差异。结论 交替化疗较之多药联合化疗治疗晚期儿童神经母细胞瘤疗效好 ,手术切除率高。毒性反应大致相同 ,两组生存期也大致相同
Objective To observe the curative effect, toxicity and survival of alternated and multi-drug combined chemotherapy for advanced neuroblastoma in children. Methods 29 cases of advanced neuroblastoma were given preoperative or postoperative chemotherapies, 14 cases were treated with COA / VIP or VP regimen and 15 cases were treated by alternation chemotherapy. Fifteen cases were treated with COPE and other multi-drug combination chemotherapy for a total of 84 courses. Results In the 14 patients with alternated chemotherapy, 13 patients were evaluated for CR 0, PR 12, NC 1 and PD 0. Effective rate of 12/13 (92.3%). The complete resection rate after chemotherapy was 10/13 (76.9%). Multi-drug combination chemotherapy group of 15 cases, evaluation of efficacy in 11 cases, CR1 cases, PR5 cases, NC3 cases, PD2 cases, the effective rate 6/11 (4.5%). Surgical resection rate after chemotherapy was 5/11 (45.5%). The two groups were compared P <0. 05 (X2 test), the main toxicity of chemotherapy was myelosuppression, nausea and vomiting, are reversible. Survival of two groups compared by rank sum test P> 0.05. No significant difference. Conclusion Compared with multi-drug chemotherapy combined with chemotherapy for advanced neuroblastoma, ALT has good curative effect and high resection rate. Toxicity is about the same, the two groups are about the same survival