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目的运用多普勒组织成像(DTI)技术评价邓老冠心方治疗冠心病心绞痛气虚痰瘀证的临床疗效。方法采用随机对照试验研究方法,纳入患者90例。观察组45例,采用邓老冠心方+西医基础治疗;对照组45例,采用消心痛+西医基础治疗,疗程12周。通过DTI技术测量治疗前后LVDd、LVDs、EF、FS、IVRT、室壁运动积分,记录中医证候积分、临床有效率的变化,评价其安全性。结果共纳入患者90例,脱落10例,两组最后各纳入40例,LVDd、LVDs IVRT治疗前后及组间比较差异无统计学意义;EF、FS、室壁运动积分治疗后比较,差异均有统计学意义(P<0.01),两组比较差异均无统计学意义;中医证候积分、临床有效率治疗前后比较,差异有统计学意义(P<0.01)。结论尚不能证明邓老冠心方治疗冠心病心绞痛气虚痰瘀证能够改善心脏结构,但可以改善心脏的收缩、舒张功能,提高心肌收缩力,增强泵血功能,改善临床症状,临床上值得进一步的研究以及推广。
Objective To evaluate the clinical efficacy of Denglao Guanxin Recipe in treating angina pectoris phlegm and blood stasis syndrome with Doppler tissue imaging (DTI). Methods Randomized controlled trials were conducted in 90 patients. The observation group of 45 cases, using Deng Lao Guan Xin Fang + Western medicine treatment; control group of 45 cases, the use of traditional Chinese medicine Xiao Xiao Xitong treatment, treatment for 12 weeks. The changes of LVDd, LVDs, EF, FS, IVRT, wall motion score, TCM syndrome score and clinical effective rate were measured by DTI technique before and after treatment, and the safety was evaluated. Results A total of 90 patients were enrolled in this study. Ten patients were lost and 40 patients were finally enrolled in both groups. There was no significant difference between before and after treatment of LVDd and LVDs IVRT. EF, FS, wall motion score after treatment were significantly different (P <0.01). There was no significant difference between the two groups (P <0.01). There was significant difference between TCM syndrome score and clinical effective rate before and after treatment (P <0.01). Conclusion Danglaiguanxinfang can not improve the heart structure of CHD angina pectoris phlegm and blood stasis syndrome, but it can improve cardiac systolic and diastolic function, improve myocardial contractility, enhance blood pump function and improve clinical symptoms, which is worth further clinical Research and promotion.