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目的探讨新疆慢性乙型肝炎病毒(HBV)感染者基因型分布情况和临床特征。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)的方法,分析2007年在新疆医科大学第一附属医院就诊的331例慢性HBV感染者基因型与临床特点。结果 331例慢性HBV感染者中,HBV B基因型占14.8%(49/331),C基因型占72.8%(241/331),C/D重组体占9.7%(32/331),D基因型占2.7%(9/331)。4种基因型中,C基因型所占比例明显高于B基因型、C/D重组体和D基因型。C基因型在乙型肝炎e抗原(HBeAg)阳性、慢性乙型肝炎(CH)、乙肝肝硬化(LC)、乙肝肝癌(HCC)患者中所占比例明显高于B基因型、C/D重组体、D基因型,差异均有统计学意义(P<0.05)。4种基因型在性别、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、血清白蛋白(ALB)等方面比较,差异无统计学意义(P均>0.05)。结论新疆地区HBV感染者,HBV基因型以C基因型为主,慢性乙型肝炎C基因型病情重,预后差。
Objective To investigate the genotype distribution and clinical features of patients with chronic hepatitis B virus infection in Xinjiang. Methods The genotypes and clinical features of 331 chronic HBV infected patients who were treated in the First Affiliated Hospital of Xinjiang Medical University in 2007 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results Of the 331 patients with chronic HBV infection, HBV B genotype accounted for 14.8% (49/331), C genotype accounted for 72.8% (241/331), C / D recombinant accounted for 9.7% (32/331), D gene Type accounted for 2.7% (9/331). Among the four genotypes, the proportion of C genotype was significantly higher than that of B genotype, C / D recombinants and D genotypes. C genotype in patients with hepatitis B e antigen (HBeAg) -positive, chronic hepatitis B (CH), hepatitis B cirrhosis (LC), hepatitis B hepatocellular carcinoma (HCC) was significantly higher than the B genotype, C / D recombination Body, D genotype, differences were statistically significant (P <0.05). There were no significant differences among the four genotypes in gender, ALT, TBI, ALB and so on (P> 0.05). Conclusion In Xinjiang, HBV genotypes are predominantly genotype C and genotype C of chronic hepatitis B is seriously ill with poor prognosis.