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肝硬化是各种慢性肝病的终末期表现,近几年兴起的干细胞移植治疗肝硬化具有操作简单、可重复进行、免疫源性弱、治疗费用低等优点,有望成为一种有广阔应用前景的治疗方法。利用干细胞治疗肝硬化有经外周静脉、门静脉、肝动脉、肝内、腹腔等多种移植途径,但是比较移植途径的实验研究报道较少,不同移植途径的疗效对比尚无定论。本文就干细胞移植治疗肝硬化的移植途径及其优缺点作一综述。
Cirrhosis is the end stage of various chronic liver diseases. In recent years, the rise of stem cell transplantation for the treatment of liver cirrhosis has the advantages of simple operation, repeatable, weak immunogenicity and low treatment cost, which is expected to become a promising application treatment method. The use of stem cells for the treatment of cirrhosis of the peripheral vein, portal vein, hepatic artery, liver, abdominal and other transplant pathways, but the experimental comparison of transplantation less reported, the efficacy of different transplantation pathological comparison is inconclusive. This review summarizes the approaches and advantages and disadvantages of stem cell transplantation in the treatment of liver cirrhosis.