Progranulin(PGRN)has recently emerged as a key player in a subset of frontotemporal dementias(FTD).Numerous mutations in the progranulin gene have been identifi
In December this year,the 4th Tianqin Cao Memorial Symposium on Protein Research will be held in Xiamen(Amoy).On this occasion,it is my pleasure to write a rec
Genetic manipulation of human pluripotent stem cells (hPSCs) provides a powerful tool for modeling diseases and developing future medicine.Recently a number of
Recent studies have unequivocally established the link between FTO and obesity.FTO was biochemically shown to belong to the AlkB-like family DNA/RNA demethylase
Stem cells and progenitor cells are the cells of origin for multi-cellular organisms and organs.They play key roles during development and their dysregulation g
c-Jun,the most extensively studied protein of the activator protein-1 (AP-1) complex,is involved in numerous cell activities,such as proliferation,apoptosis,sur
Synthetic biology aims to design and build new biological systems with desirable properties,providing the foundation for the biosynthesis of secondary metabolit