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目的了解200 mg碘油胶丸对哺乳妇女乳汁碘及婴幼儿尿碘的有效保护期,并探索碘排泄规律。方法在阿克苏地区库车县牙哈镇四村选择了109名近半年内未服用过碘油丸的19～36岁哺乳期妇女及20天～18个月婴幼儿,用现场干预的方法,并于服药后的第1、3、7、14、30、50、75、100 d分别采集实验组及对照组的妇女乳汁及婴幼儿尿样,进行碘含量测定。结果本次研究哺乳妇女口服200 mg碘油胶丸后,乳汁碘及婴幼儿尿碘中位数在干预后第一天达到峰值,其值为1004.1μg/L、1383.9μg/L,1～7 d维持高值段,7～14 d碘值下降较快,14 d以后碘值缓慢下降,75～100 d碘值缓慢上升。干预组与对照组经非参数wilcoxon秩和检验显示,除了乳汁碘100 d外,干预组均大于对照组,差异有统计学意义(P<0.05)。结论库车牙哈镇哺乳期妇女通过口服200 mg碘油胶丸可对婴幼儿尿碘最长保护期为100 d。
Objective To understand the effective protection period of 200 mg iodized oil capsules on milk iodine and urinary iodine in infants and young children, and explore the rule of iodine excretion. Methods A total of 109 lactating women aged 19-36 years and infants aged 20 days to 18 months who had not taken iodized oil pills in the past six months were enrolled in the four villages of Yaha Town, Kuqa County, Aksu Prefecture. On the 1st, 3rd, 7th, 14th, 30th, 50th, 75th and 100th days after taking the medicine, the urine and milk of women and infants in the experimental group and the control group were collected to determine the iodine content. Results In this study, the median of urinary iodine of milk iodine and infants and young children reached the peak on the first day after lactation, with the values of 1004.1μg / L, 1383.9μg / L and 1-7 d maintained a high value segment, the iodine value decreased rapidly from 7 to 14 days, the iodine value decreased slowly after 14 days, and the iodine value increased slowly from 75 to 100 days. The non-parametric wilcoxon rank sum test showed that the intervention group and the control group were significantly larger than the control group except milk iodine 100 d (P <0.05). Conclusion The longest duration of urinary iodine protection for infants and young children was 100 days after oral administration of 200 mg iodized oil capsules.