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目的探讨胃肠道间质瘤(GIST)中P21WAF1和Bax的表达与生物学行为的关系。方法运用免疫组化SP法检测P21WAF1和Bax在胃肠道间质瘤中的表达情况,并分析其在良性、潜在恶性、恶性病例中的表达差异。结果 55例GIST中,P21WAF1和Bax的阳性表达率分别为54.5%和60.0%。P21WAF1和Bax的表达随着恶性程度的增加而增加,与良性组相比差异有统计学意义(P<0.05)。P21WAF1与Bax的表达有显著相关性。结论检测P21WAF1和Bax可作为预测胃肠道间质瘤恶性潜能的重要参考指标。
Objective To investigate the relationship between the expression of P21WAF1 and Bax and the biological behavior in gastrointestinal stromal tumors (GIST). Methods The expression of P21WAF1 and Bax in gastrointestinal stromal tumors was detected by immunohistochemical SP method, and their differences in benign, potentially malignant and malignant cases were analyzed. Results The positive expression rates of P21WAF1 and Bax in 55 cases of GIST were 54.5% and 60.0% respectively. The expression of P21WAF1 and Bax increased with the increase of the degree of malignancy, the difference was statistically significant compared with the benign group (P <0.05). P21WAF1 and Bax expression was significantly correlated. Conclusion Detection of P21WAF1 and Bax can be used as important reference indexes for predicting the malignant potential of gastrointestinal stromal tumors.