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用左旋咪唑治疗免疫性疾病收到了良好效果,但对其副作用报道较少.本文报道4例左旋咪唑所致的急性粒细胞缺乏症,临床资料见附表.讨论左旋咪唑为一种广谱驱虫药,1971年Rcnoux 等偶尔发现它具有免疫激发作用,其副作用出现率达15～20%,常见为胃肠道反应、皮疹、流感样综合征、口腔溃疡等.Parkinson 等(1977)报道可引起严重的致死性或非致死性粒细胞缺乏症.钱泽鉴等(1979)报告100例长期使用左旋咪唑的患者2例发生粒细胞减少,Clora 报告23例因左旋咪唑所致粒细胞减少患者中有3例死亡,而此3例均曾长期大量应用皮质激素.两年来我们应用左旋咪唑治疗 CAA 及 ITP80余例,4例发生急性粒细胞缺乏症.本文4例内服左旋咪唑后并发急性粒细
With levamisole treatment of immune disease has received good results, but less side effects reported.This paper reports four cases of levamisole-induced acute agranulocytosis, clinical data, see the attached table.Levamisole is a broad-spectrum drive Insecticide, Rcnoux occasionally found it has immunostimulant effect in 1971, the side effects of 15% to 20%, common gastrointestinal reactions, rash, influenza-like syndrome, oral ulcers, etc. Parkinson et al (1977) reported that Causing serious fatal or nonfatal agranulocytosis Qian Qian Jian et al (1979) reported 100 cases of long-term use of levamisole in 2 patients with neutropenia, Clora reported 23 cases of patients with levamisole induced neutropenia In 3 cases of death, and these three cases have long-term large-scale use of corticosteroids .In two years we use levamisole CAA and ITP80 more than cases, 4 cases of acute agranulocytosis.In this paper, 4 cases of oral levamisole combined with acute granulocyte fine