蛋白质糖基化是一种重要的翻译后修饰,50%以上的蛋白质存在糖基化现象[1]。蛋白质糖基化涉及到细胞免疫、细胞粘附、蛋白翻译调控、蛋白降解等多种生物过程。在肿瘤的发生、发展进程中,某些糖基化修饰会随着疾病进程发生改变,因此寻找这些特征性改变对于肿瘤的早期诊断、进程监测、预后 Glycosylation of protein is an important post-translational modification, and more than 50% of proteins have glycosylation [1]. Protein glycosylation involves many biological processes such as cellular immunity, cell adhesion, protein translation regulation and protein degradation. In the process of tumorigenesis and development, some glycosylation changes with the progress of the disease, so looking for these characteristic changes for the early diagnosis of tumors, process monitoring, prognosis