大车前是世界范围广泛分布的一种温带植物。大车前叶具有多种生物学作用, 如抗炎、抗微生物、抗肿瘤等,但其免疫增强作用的机制尚未阐明。本次观察了大车前叶甲醇提取物体外对大鼠腹腔巨噬细胞和胸腺淋巴细胞的作用。巨噬细胞在抗感染性疾病和抗癌作用中的体液免疫和细胞免疫调节反应中起重要作用。免疫调节剂如IFN-γ和LPS能激活巨噬细胞,活化的巨噬细胞可产生细胞毒媒介因子如NO In front of the cart is a kind of temperate plant widely distributed around the world. The anterior branch of the cart has a variety of biological effects, such as anti-inflammatory, anti-microbial, and anti-tumor, but the mechanism of its immune enhancement has not yet been elucidated. This study was conducted to observe the effects of methanol extracted from the anterior part of the carts on rat peritoneal macrophages and thymocytes. Macrophages play an important role in humoral and cellular immune response in anti-infectious diseases and anti-cancer effects. Immunomodulators such as IFN-γ and LPS activate macrophages and activated macrophages produce cytotoxic mediators such as NO