在干扰素治疗丙型肝炎的临床使用中已出现心血管不良事件的报道,但多为个案报道,经报道的患者几乎均为接受高剂量干扰素治疗、本身有心脏疾病或以前接受造成心脏损害药物治疗的患者。而丙型肝炎病毒本身可通过刺激机体产生细胞因子、诱导心肌线粒体损伤等众多途径对心肌造成损伤,其极易变异,可逃避宿主免疫而长期存在于人体内。故干扰素引起心血管不良反应可能被夸大了。在治疗过程中,如定期监测心功能的敏感指标(如心肌肌钙蛋白),发现异常尽早对症处理,干扰素的使用将是安全的。 Cardiovascular adverse events have been reported in the clinical use of interferon in the treatment of hepatitis C, but are mostly case reports. Almost all of the reported patients were treated with high-dose interferon, with heart disease or previous heart damage Medically treated patients. The hepatitis C virus itself can stimulate the body to produce cytokines, myocardial mitochondrial damage induced myocardial damage and many other ways to cause myocardial damage, its highly variable, can evade the host immune and long-term presence in the human body. Therefore, interferon-induced cardiovascular adverse reactions may be exaggerated. In the course of treatment, such as regular monitoring of cardiac function of sensitive indicators (such as cardiac troponin), abnormal early detection of symptomatic treatment, the use of interferon will be safe.