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目的 :探讨蛛网膜下腔出血 (subarachnoidhemorrhage ,SAH)患者不同时期血浆D二聚体情况 ,寻找SAH抗纤溶治疗及观察病情变化的实验室指标。方法 :抽取 30例正常对照组及 2 5例住院SAH患者治疗前、治疗后 2、3、4周血 ,用ELISA法定量检验D二聚体含量。结果 :治疗前血浆D二聚体明显升高 ,第 4周和正常对照组比较有显著性差异 (P<0 .0 0 1 ) ,治疗后第 2 ,3,4周呈下降趋势 ,第 4周和治疗前比较有显著性差异 ( P <0 .0 5 ) ,和正常对照组比较有显著性差异。其中有 1 1例血浆D二聚体下降后又升高 ,1例再出血 ,1例脑梗死。结论 :SAH后血浆D二聚体升高 ,观察D二聚体变化有助于判定抗纤溶治疗疗效及观察病情变化。
Objective: To investigate the plasma D-dimer levels in patients with subarachnoidhemorrhage (SAH) in different periods and to find the laboratory indexes of SAH anti-fibrinolytic therapy and observation of disease changes. Methods: Thirty normal controls and 25 hospitalized SAH patients were selected before treatment and after 2, 3 and 4 weeks of treatment, and the content of D dimer was quantitatively determined by ELISA. Results: Before treatment, plasma D dimer was significantly increased, there was a significant difference between the 4th week and the normal control group (P <0. 001), the second, third and fourth week after treatment decreased, and the 4th Week and before treatment were significantly different (P <0. 05), compared with the normal control group were significantly different. Among them, 11 cases of plasma D-dimer decreased and then increased, 1 case of rebleeding and 1 case of cerebral infarction. Conclusion: The plasma D dimer is increased after SAH. To observe the change of D dimer is helpful to determine the antifibrinolytic efficacy and to observe the changes of the disease.