目的:探讨应用单唾液酸四己糖神经节苷脂钠治疗中、重度新生儿缺氧缺血性脑病(HIE)的疗效及对预后的影响,为临床治疗提供参考依据。方法:将92例中、重度HIE患儿随机分为对照组和治疗组,两组均予支持疗法和对症处理,对照组应用胞二磷胆碱,而治疗组应用单唾液酸四己糖神经节苷脂钠,两组方法及疗程相同,最后比较两组NBNA评分。所有病例均于出生后3、6、9、12个月时测定发育商(DQ),对两组临床疗效及预后进行比较。结果:治疗组呼吸改善时间、惊厥消失时间、症状及体征全部消失时间少于对照组;治疗组后遗症发生率低于对照组,治疗组NBNA评分及DQ高于对照组,差异均具有统计学意义(P<0.01)。结论:与胞二磷胆碱相比,单唾液酸四己糖神经节苷脂钠治疗中、重度HIE的总有效率有所提高,患儿惊厥易于控制,意识障碍及肌张力等神经症状及体征恢复快,且在改善HIE的预后方面效果显著,可降低后遗症发生率及新生儿死亡率,无任何不良反应,适于临床推广使用。 Objective: To investigate the therapeutic effect of monosialotetrahexosyl ganglioside on moderate and severe neonatal hypoxic-ischemic encephalopathy (HIE) and its effect on prognosis, and to provide a reference for clinical treatment. Methods: Ninety-two children with moderate and severe HIE were randomly divided into control group and treatment group. Both groups were given supportive therapy and symptomatic treatment, while citicoline was used as control group. In the treatment group, Sodium glycosides, two groups of methods and the same course of treatment, and finally compare the two groups NBNA score. All cases were measured at 3,6,9,12 months after birth, the developer (DQ), the clinical efficacy and prognosis of the two groups were compared. Results: The time of respiratory improvement, the disappearance of convulsions, the disappearance of symptoms and signs in the treatment group were all less than those in the control group. The incidence of sequelae in the treatment group was lower than that in the control group. NBNA score and DQ in the treatment group were higher than those in the control group (P <0.01). Conclusion: Compared with citicoline, monosialotetrahexosyl ganglioside sodium in the treatment of moderate and severe HIE increased the total efficiency of children with convulsions easy to control, disturbance of consciousness and muscle tone and other neurological symptoms and Rapid recovery of signs, and in improving the prognosis of HIE significant effect, can reduce the incidence of sequelae and neonatal mortality, without any adverse reactions, suitable for clinical use.