DNA甲基化(DNA m ethylation)是哺乳类动物体内极为重要的自然化学修饰方式,能调控体内基因的表达,影响细胞的增殖和分化,与动植物生长发育关系密切,是目前表观遗传学研究的热点[1],重金属镉(Cd)被美国毒理学会认为是人类致癌物质[2],镉通过遗传毒性和表观遗传毒性2种机制增加 DNA methylation (DNA methylation) is a very important natural chemical modification in mammals, which can regulate the gene expression in vivo and affect the proliferation and differentiation of cells. It is closely related to the growth and development of plants and animals, and is currently the epigenetics The focus of the study [1], heavy metal cadmium (Cd) by the American Toxicology Society is considered to be human carcinogen [2], cadmium through genotoxic and epigenetic toxicity of two mechanisms increased