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充血性心力衰竭的治疗原则是增强心肌收缩力、减轻心脏负荷和保护衰竭心肌。具有正性肌力作用的β-肾上腺素能激活剂和血管扩张药α-受体阻滯剂,在心衰治疗中占有重要位置。近年来认为β-受体阻滞剂对衰竭心肌具有保护作用。一、β-肾上腺素能激活剂β-受体激活剂是仅次子洋地黄糖甙而广泛用于心衰治疗的正性肌力药物,主要是儿茶酚胺类如多巴胺、多巴酚丁胺等,近年来又合成许多可以口服的制剂应用于临床。β-受体激活剂的作用机理与洋地黄有所不同,是通过兴奋心肌细胞膜β_1-受体,激活腺苷酸环化酶,使细胞内环腺苷酸(cAMP)浓度增加,激活蛋
The principle of treatment of congestive heart failure is to enhance myocardial contractility, reduce heart load and protect the heart failure. Beta-adrenergic activators with positive inotropic effects and vasodilator alpha-blockers play an important role in the treatment of heart failure. In recent years that beta-blockers have a protective effect on myocardial failure. First, β-adrenergic activator β-receptor activator is only the second only digitalis glycosides and is widely used in the treatment of heart failure inotropic drugs, mainly catecholamines such as dopamine, dobutamine and so on In recent years, they have synthesized many preparations that can be orally administered to the clinic. The mechanism of action of β-receptor activator is different from that of digitalis, activating adenylate cyclase by activating β 1 -receptor of myocardial cell membrane, increasing concentration of intracellular cyclic adenosine monophosphate (cAMP) and activating egg