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许多研究已报道了在成人和儿童中血浆胆固醇水平与动脉硬化之间的相互关系,预防动脉硬化应以儿童开始控制血浆高胆固醇。仅有几个主要关于成人苯妥英(PHT)、鲁米那(PB)对总胆固醇和高密度脂蛋白水平影响的报告。作者对服用抗痫药物的儿童及正常对照组儿童进行了血浆总胆固醇(TC)、高密度脂蛋白(HDL)胆固醇和甘油三脂测定。384例1～16岁儿童,208例为服单一抗痫药的癫痫患儿(平均年龄8.72岁),服药时间为3月～1年;175例正常儿童,并排除了高胆固醇家族史(平均年龄8.54岁)。结果表明,正常儿童及癫痫患儿的
Many studies have reported on the correlation between plasma cholesterol levels and atherosclerosis in adults and children, and prevention of atherosclerosis should start with children’s control of plasma hypercholesterolemia. There are only a few reports that mainly focus on the effects of adult phenytoin (PHT) and luminal (PB) on total cholesterol and high density lipoprotein levels. The authors tested the levels of total cholesterol (TC), high density lipoprotein (HDL) cholesterol and triglycerides in children taking antiepileptic drugs and normal controls. 384 children aged 1 to 16 years and 208 children with epilepsy (average age 8.72 years) who took single antiepileptic drug for a period of 3 months to 1 year; 175 normal children and excluded the high cholesterol family history (mean age 8.54 years old). The results show that normal children and children with epilepsy